Molecular basis of glutamatergic synapse function in different neuron populations
Molecular basis of glutamatergic synapse function in different neuron populations
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From electrophysiological experiments it is known that glutamatergic (excitatory) synapses in different neuronal populations have different properties and "rules" for plasticity. However, the molecular basis supporting these differences is poorly understood. Our lab is particularly interested in the composition, and regulation, of glutamatergic synapses located within GABAergic (inhibitory) interneurons. We seek to identify and evaluate proteins that are enriched at glutamatergic synapses in inhibitory interneurons. One such protein is Btbd11, for which we recently published a paper.
In the long term, we believe this research could uncover new ways to manipulate glutamatergic synapse in a cell type-specific manner--to help regulate neuronal circuit function.
In the long term, we believe this research could uncover new ways to manipulate glutamatergic synapse in a cell type-specific manner--to help regulate neuronal circuit function.
Research Methods
Research Methods
We utilize broad methods to evaluate glutamatergic synapse function including:
Genetic mouse models
Molecular biology
Biochemistry
Live-cell confocal imaging
Behaviour
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